Principal Research Interests
Research in Professor Noland’s group is focused on heterocyclic nitrogen and/or sulfur chemistry, including the chemistry of nitro compounds, with emphasis on synthesis, mechanisms, and submission of compounds for testing for medicinal activity. To date, activity has been found against cancer (in two classes of compounds), AIDS, tuberculosis, and plants, including fungi. Currently, emphasis is also being placed on the synthesis of benzofurazan oxides, nitriles, isonitriles, and their analogs, to observe interactions, especially with halogens, in the crystalline state. This is being carried out in a fruitful collaboration with the late-Professor Emeritus Doyle Britton, who founded the department’s X-ray crystallographic laboratory.
Recent Publications and News Items
Noland, W. E.; Kumar, H. V.; Lu, C.; Brown, C. D.; Wiley-Schaber, E.; Johansson, A.; LaBelle, E. V.; O'Brian, N. C.; Jensen, R. C.; Tritch, K. J. Tetrahedron Letters. 2016, 57, 2158
Noland, W. E.; Kumar, H. V.; Flick, G. C.; Aspros, C. L.; Yoon, J. H.; Wilt, A. C.; Dehkordi, N.; Thao, S.; Schneerer, A. K.; Gao, S.; Tritch, K. J. Tetrahedron, 2017, 73, 3913.
Noland WE, Herzig RJ, Engwall AJ, Jensen RC, Tritch KJ. Acta Crystallogr E Crystallogr Commun. 2018, 13;74(Pt 3):345-348.
Tritch, K. J.; Capek, J. A.; Klein, N. D.; Noland, W. E. ChemSpider Synthetic Pages 2017, 815, 1.
Noland WE, Brown CD, DeKruif RD, Lanzatella NP, Gao SM, Zabronsky AE, Tritch KJ, Synthetic Communications, 2018, 48, 1755-1765